CAS number：1254053-43-4 molecular formula：C29H44N8O3
Gilteritinib 是小分子FLT3/AXL抑制剂，对FLT3和AXL的IC50值为0.29 nM和0.73 nM。其抑制c-KIT的IC50值约为抑制FLT3的800倍。 product description： Gilteritinib (ASP2215) is a small-molecule FLT3/AXL inhibitor with IC50 values of 0.29 nM and 0.73 nM for FLT3 and AXL, respectively. It inhibits FLT3 at an IC50 value that was approximately 800-fold more potent than the concentration required to inhibit c-KIT (230 nM).
| Chinese alias | - | ||
| English alias | GILTERITINIB [WHO-DD] | Gilteritinib HCl | NCGC00481652-01 | AS-35199 | GILTERITINIB [MI] | 1,4-Oxadiazole, 2-(o-hydroxyphenyl)- | 2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyr | ||
| CAS number | 1254053-43-4 | molecular formula | C29H44N8O3 |
| molecular weight | 552.7115 g/mol | Exact mass | - |
| PSA | 121.000 Ų | logp | 3.5 |
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