compound introduction
Pyrotinib (SHR-1258) 是有效、选择性的 EGFR/HER2 双重抑制剂，IC50 值分别为 13 nM 和 38 nM。 Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively.
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pyrotinib
CAS number：1269662-73-8 molecular formula：C32H31ClN6O3
overview
Specs
| Chinese alias | - | ||
| English alias | SHR1258 | SHR-1258 | SCHEMBL9948753 | compound 12 [PMID: 28115222] | GTPL9662 | WZB08997 | (R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide | SADXACCFNXBCFY-IYNHSRRRSA-N | 4679 | ||
| CAS number | 1269662-73-8 | molecular formula | C32H31ClN6O3 |
| molecular weight | 583.08 g/mol | Exact mass | - |
| PSA | 112.000 Ų | logp | 5.400 |
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