CAS number：1416241-23-0 molecular formula：C29H27F3N6O
Vamotinib (PF-114) 是一种具有特异性的酪氨酸激酶抑制剂，具有抗增殖和抗肿瘤活性。Vamotinib 抑制 BCR/ABL 和 BCR/ABL-T315I 的磷酸化，促使细胞凋亡。Vamotinib 可用于研究耐药性费城染色体阳性 (Ph+) 白血病和阿尔茨海默症。 Vamotinib (PF-114) is a specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.
| Chinese alias | - | ||
| English alias | I8C3R768IZ | US9522910, Table 1 Compound 1: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethynyl)benzamide | HY-147414 | SCHEMBL15789568 | GTPL9792 | UNII-I8C3R768IZ | vamotinib [INN] | | ||
| CAS number | 1416241-23-0 | molecular formula | C29H27F3N6O |
| molecular weight | 532.56 g/mol | Exact mass | - |
| PSA | 65.800 Ų | logp | 5.000 |
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