Zongertinib 是一种人类HER2选择性酪氨酸激酶抑制剂,是一种高度选择性共价结合在HER2酪氨酸激酶域 (TKD)的新型TK。Zongertinib 具有抗肿瘤活性,对 pHER2 和 EGF 具有抑制作用。 Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD).Zongertinib exhibits antitumor activity with inhibitory effects on pHER2 and EGF.
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Zongertinib
CAS number:2728667-27-2 molecular formula:C29H29N9O2
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| Chinese alias | - | ||
| English alias | EX-A8033 | HY-148810 | Zongertinib | DRH7R67UVL | example I-01 [WO2021213800A1] | N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxyanilino]pyrimido[5,4-d]pyrimidin-6-yl]piperidin-4-yl]prop-2-enamide | GTPL12387 | SCHEMBL23957509 | N-[1-(8-{3-methyl-4-[(1 | ||
| CAS number | 2728667-27-2 | molecular formula | C29H29N9O2 |
| molecular weight | 535.60 g/mol | Exact mass | - |
| PSA | 123.000 Ų | logp | 4.100 |
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