CAS number：1239358-86-1 molecular formula：C21H20FN7
Ilginatinib (NS-018) 是一种高度有效的 JAK2 抑制剂，IC50 值为 0.72 nM，对其选择性是对 JAK1 的 46 倍 (IC50, 33 nM)，JAK3 的 54 倍 (IC50, 39 nM)，以及 Tyk2 的 22 倍 (IC50, 22 nM)。 Ilginatinib (NS-018) is a highly active JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).
| Chinese alias | 伊格替尼 | ||
| English alias | N2-[(1S)-1-(4-Fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-2,6-pyridinediamine | GS-3039 | -N-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methylpyrazol-4-yl)-2-N-pyrazin-2-ylpyridine-2,6-diamine | NS018 | NS-018 | 1239358-86-1 | ||
| CAS number | 1239358-86-1 | molecular formula | C21H20FN7 |
| molecular weight | 389.43 g/mol | Exact mass | - |
| PSA | 80.600 Ų | logp | 3.200 |
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