NVP-ACC789 is an inhibitor of human VEGFR-1 , VEGFR-2 (mouse VEGFR-2 ), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In Vitro The enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC 50 s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC 50 of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:VEGFR-2 0.02 μM (IC 50 ) VEGFR-1 0.38 μM (IC 50 ) mVEGFR-2 0.23 μM (IC 50 ) VEGFR-3 0.18 μM (IC 50 ) PDGFR-β 1.4 μM (IC 50 )
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NVP-ACC789
CAS number：300842-64-2 molecular formula：C21H17BrN4
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| Chinese alias | - | ||
| English alias | FT-0687662 | ZK 202650 | AKOS015917936 | ZK202650 | ZK-202650 | NVP-ACC789 | NVP-ACC-789 | ACC-789;ZK202650 | DTXSID80426082 | N-(3-bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine | MS-26927 | SCHEMBL1652070 | ACC789 | ACC-789 | ACC-789 (NV | ||
| CAS number | 300842-64-2 | molecular formula | C21H17BrN4 |
| molecular weight | 405.3 g/mol | Exact mass | ≥99% |
| PSA | 50.700 Ų | logp | 4.900 |
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