PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 µM; K i =5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622 Appearance:Solid IC50& Target:CSF1R In Vitro:PLX5622 (1-20 μM; 3 days) hemifumarate effectively depletes microglia without affecting oligodendrocytes or astrocytes in cerebellar slices. PLX5622 (4 μM; 3 days) hemifumarate causes a 30-40% reduction in NG2+ or PDGFRα+ cells, and this increased to 90-9 In Vivo:Pharmacodynamics of PLX5622 hemifumarate in preclinical studies PLX5622 (1200 ppm; chow; for 3 weeks or 3 days; adult C57/Bl6 wild type mice) hemifumarate leads to around 80% of microglia lost after 3 days of treatment and a 99% microglia loss after 3 wee Biological Activity:PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor ( IC 50 =0.016 µM; K i =5.9 nM). PLX5622 hemifumarate allows for extended and specific microglial elimination, preceding and during pathology development. PLX5622
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PLX5622 hemifumarate
CAS number：unknown molecular formula：C23H21F2N5O3
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| Chinese alias | PLX5622 半富马酸盐 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C23H21F2N5O3 |
| molecular weight | 453.45 g/mol | Exact mass | ≥99% |
| PSA | - | logp | - |
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