应用： Camizestrant (Estrogen receptor antagonist 2) 是一种雌激素受体拮抗剂，可用于 ER+ HER2 晚期乳腺癌的研究。 Information AZD9833 is an orally available and selectiveestrogen receptor (ER)antagonist with antineoplastic activity. Targets ER In vitro AZD9833 is demonstrated to be a highly potent selective estrogen receptor degraders (SERD) that shows a pharmacological profile comparable to fulvestrant in its ability to degrade ERα in both MCF-7 and CAMA-1 cell lines. In vivo A stringent control of lipophilicity ensures that AZD9833 has favorable physicochemical and preclinical pharmacokinetic properties for oral administration. AZD9833 is potent in vivo activity in mouse xenograft models. Cell Research(from reference) Cell lines：MCF-7 cells Concentrations：100 nM Incubation Time：24 h
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Camizestrant
CAS number：2222844-89-3 molecular formula：C24H28F4N6
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| Chinese alias | 卡米泽司特兰 | ||
| English alias | AZD9833 | AZD-9833 | N-[1-(3-fluoropropyl)azetidin-3-yl]-6-[(6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]pyridin-3-amine | N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((6S,8R)-8-methyl-7-(2,2,2-trifluoroethyl)-6,7, | ||
| CAS number | 2222844-89-3 | molecular formula | C24H28F4N6 |
| molecular weight | 476.51 g/mol | Exact mass | ≥99% |
| PSA | 60.100 Ų | logp | 4.2 |
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