TEI-9648, a Vitamin D 3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH) 2 D 3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH) 2 D 3. TEI-9648 has the potential for bone metabolism research. In Vitro TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH) 2 D 3. TEI-9648 has consistently weaker suppressive effect than TEI-9647. TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell. TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH) 2 D 3 (0.1 nM) in HL-60 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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TEI-9648
CAS number：173388-21-1 molecular formula：C27H38O4
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| Chinese alias | - | ||
| English alias | TEI 9648 | HY-12398A | LMST03020600 | TEI-9648 | CHEBI:197108 | MS-27531 | 2(3H)-Furanone, 5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]propyl]dihydro-3-methylene-, (5R | ||
| CAS number | 173388-21-1 | molecular formula | C27H38O4 |
| molecular weight | 426.59 g/mol | Exact mass | - |
| PSA | 66.800 Ų | logp | 4.800 |
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