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Pomalidomide-PEG2-butyl iodide

CAS number:1835705-72-0    molecular formula:C23H28IN3O7

overview

compound introduction

Product Application: 1、Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. 2、Pomalidomide-PEG2-butyl iodide (CAS No.1835705-72-0) is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal iodoalkane that reacts with the nucleophilic group of the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation.

Specs

Chinese alias泊马度胺-PEG2-丁基碘
English aliasCrosslinker–E3 Ligase ligand conjugate, Partial PROTAC, Pomalidomide-2-2-6-I, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-((6-iodohexyl)oxy)ethoxy)acetamide, Template for synthesis of targeted protein degrader
CAS number1835705-72-0molecular formulaC23H28IN3O7
molecular weight585.39 g/molExact mass≥95%
PSA-logp-

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1835705-72-0 | Pomalidomide-PEG2-butyl iodide.pdf