compound introduction
BAY 60-6583 是腺苷 A2B受体 的高效选择性激动剂， 对 A2B 受体 (EC50= 3 nM) 的选择性高于 A1，A2A 和 A3 受体。BAY 60-6583 可以与小鼠，兔和狗 A2BAR 结合，Ki 值分别为 750 nM，340 nM 和 330 nM。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。 Product description BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50 = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.
