一种单链糖蛋白，抑制C1、C1r、C1s、血浆激肽释放酶、因子XIa。XIIa和纤溶酶。血浆中存在16-33mg/100ml的C1酯酶抑制剂缺乏症是一种罕见的疾病，会导致面部肿胀和腹部绞痛。通常情况下，这种情况是遗传性的，尽管当C1EI不起作用时也可能发生。 A single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, Factors XIa. XIIa, and plasmin. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary, though it may also occur when the C1EI is non-functional. Product Citation: Salvesen, G.S et al. 1985. J. Biol. Chem. 260, 2432. Lee, Kyoung Geun, Haneulnari Lee, Jeong Mi Ha, Young Kyung Lee, Hee Jung Kang, Chung‐Gyu Park, and Sang Joon Kim. "Increased human tumor necrosis factor‐α levels induce procoagulant change in porcine endothelial cells in vitro."Xenotransplantation 19, no. 3 (2012): 186-195 Kang, Hee Jung, Haneulnari Lee, Jeong-mi Ha, Jae-il Lee, Jun-Seop Shin, Ki-Yong Kim, Ji Yoon Park et al. "The Role of the Alternative Complement Pathway in Early Graft Loss After Intraportal Porcine Islet Xenotransplantation." Transplantation (2014) Kenninston JA, et al. Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody. J Biol Chem. 2014 Aug 22;289(34):23596-608. doi: 10.1074/ jbc.M114.569061. Epub 2014 Jun 26. Zamolodchikov D, Renner T, Strickland S. The Alzheimer's disease peptide β-amyloid promotes thrombin generation through activation of coagulation factor XII. J Thromb Haemost. 2016 May;14(5):995-1007. doi: 10.1111/jth.13209. Epub 2016 Feb 29.
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C1酯酶抑制剂,人血浆
CAS number：unknown molecular formula：
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compound introduction
Specs
| Chinese alias | Complement C1 esterase inhibitor, Esterase inhibitor C-1 | ||
| English alias | Complement C1 esterase inhibitor | Esterase inhibitor C-1 | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | ≥95%(SDS-PAGE) |
| PSA | - | logp | - |
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