Purity: >95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： Cyclophilin A, also called Peptidyl-prolyl Isomerase A, PPIA, CYPA, and CYPH, was originally characterized for its ability to catalyze the transition between cis- and trans-proline residues critical for proper folding of proteins. Cyclophilin is also incorporated into many viruses, including HIV-1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.
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Recombinant Human Cyclophilin A Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人Cyclophilin A蛋白 | 重组人类环丝氨酸蛋白酶A | ||
| English alias | Cyclophilin A | Cyclosporin A-binding protein | CYPA | CYPAMGC12404 | CYPH | EC 5.2.1.8 | MGC117158 | MGC23397 | peptidyl-prolyl cis-trans isomerase A | peptidylprolyl isomerase A (cyclophilin A) | PPIA | PPIase A | Rotamase A | Rotamase | T cell cyclophi | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无载体 |
| PSA | - | logp | - |
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