Gardiquimod diTFA, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod diTFA could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 when used at concentrations below 10 μM In Vitro Gardiquimod diTFA (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)Dosage: 1 mg/kg per mouse Administration: i.p.; daily for 7 days Result: Significantly suppressed the growth of human HepG2 liver carcinoma xenografts. Form:Solid IC50& Target:TLR7 TLR8 HIV-1
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Gardiquimod diTFA
CAS number：1159840-61-5 molecular formula：C21H25F6N5O5
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| Chinese alias | 加地喹莫特二三氟乙酸 | ||
| English alias | 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-alpha,alpha-dimethyl-, 2,2,2-trifluoroacetate (1:2) | 4Y6M4HJ0WU | 1H-IMIDAZO(4,5-C)QUINOLINE-1-ETHANOL, 4-AMINO-2-((ETHYLAMINO)METHYL)-.ALPHA.,.ALPHA.-DIMETHYL-, 2,2,2-TRIFLUOROACETATE | ||
| CAS number | 1159840-61-5 | molecular formula | C21H25F6N5O5 |
| molecular weight | 541.4 g/mol | Exact mass | ≥99% |
| PSA | 164.000 Ų | logp | - |
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