QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC 50 of 7 nM . In Vitro QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, most likely by targeting an early step in translation elongation. QL47 inhibits autophosphorylation of BTK on Tyr223 in cells with an EC 50 of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC 50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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QL47
CAS number：1469988-75-7 molecular formula：C27H21N5O2
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| Chinese alias | - | ||
| English alias | BDBM50245587 | HMS3265M21 | QL47 | QL-47 | HMSL10077 | MS-28101 | 1-(1-Acryloylindolin-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one | 9-(1-methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one | ||
| CAS number | 1469988-75-7 | molecular formula | C27H21N5O2 |
| molecular weight | 447.49 g/mol | Exact mass | ≥98% |
| PSA | 71.300 Ų | logp | 3.300 |
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