CAS number：1223001-51-1 molecular formula：C24H15F3N4O
Torin 2是一种有效的，选择性的mTOR抑制剂，IC50为0.25 nM；作用于mTOR比作用于PI3K选择性高800倍，且增强药代动力学特性，抑制ATM/ATR/DNA-PK，EC50分别为28 nM/35 nM/118 nM。 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.
| Chinese alias | - | ||
| English alias | 9-(6-AMINOPYRIDIN-3-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]-1H,2H-BENZO[H]1,6-NAPHTHYRIDIN-2-ONE | Torin2 | Torin-2 | HY-13002 | AS-74405 | B-5680 | 17G | 9-(6-amino-3-pyridyl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one | NSC760387 | 9-(6-Amin | ||
| CAS number | 1223001-51-1 | molecular formula | C24H15F3N4O |
| molecular weight | 432.4 g/mol | Exact mass | - |
| PSA | 72.100 Ų | logp | 4.400 |
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