Bonannione A (6-Geranylnaringenin; Mimulone) 是一种异戊二烯类黄酮,一种口服有效的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,IC50为 14 µM。Bonannione A 触发半胱天冬酶依赖性细胞凋亡。Bonannione A 通过 p53 介导的 AMPK/mTOR 通路诱导自噬。Bonannione A 显示出抗炎、抗自由基和抗癌活性。
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Bonannione A
CAS number:97126-57-3 molecular formula:
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 97126-57-3 | molecular formula | |
| molecular weight | 408.500 g/mol | Exact mass | - |
| PSA | 87.000 Ų | logp | 6.200 |
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