Purity: ≥95%, by SDS-PAGE visualized with Coomassie® Blue Staining. Description： TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
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Recombinant Human TROP-2 Protein
CAS number：unknown molecular formula：
overview
compound introduction
Specs
| Chinese alias | 重组人TROP-2蛋白 | 重组人 TROP-2 蛋白 | ||
| English alias | Pancreatic carcinoma marker protein GA7331 | TACD 2 | TACD2_HUMAN | TACSTD 2 | Tacstd2 | Trop 2 | Trop2 | Tumor associated calcium signal transducer 2 precursor | Tumor-associated calcium signal transducer 2 | Cell surface glycoprotein Trop 2 | Cell surfa | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | 无动物源 |
| PSA | - | logp | - |
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