compound introduction
LDK378是一种有效的ALK抑制剂，IC50为0.2 nM，作用于IGF-1R和InsR，选择性分别为40和35倍。 LDK378 is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.
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LDK378
Dangerous GoodsCAS number：1032900-25-6 molecular formula：C28H36ClN5O3S
overview
Specs
| Chinese alias | 色瑞替尼 | ||
| English alias | K418KG2GET | 5-chloro-2-N-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-4-N-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine | 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidin | ||
| CAS number | 1032900-25-6 | molecular formula | C28H36ClN5O3S |
| molecular weight | 558.14 g/mol | Exact mass | - |
| PSA | 114.000 Ų | logp | 6.4 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS07
Signal word：
Danger
Hazard Statement：
H302: 吞食有害 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子
Statement of Preventive Measures：
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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