AZD4547

Dangerous Goods

CAS number：1035270-39-3 molecular formula：C26H33N5O3

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

AZD4547是一种新型选择性的FGFR抑制剂，靶向作用于FGFR1/2/3，IC50为0.2 nM/2.5 nM/1.8 nM，对FGFR4， VEGFR2(KDR)具有微弱的作用活性，对IGFR， CDK2和p38几乎没有作用活性。Phase 2/3。A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3. AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3. A novel selective FGFR inhibitor targeting FGFR1, FGFR2, and FGFR3.

Specs

Chinese alias	-
English alias	J-000994 \| N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide \| NSC799346 \| NSC-799346 \| AZD 4547 \| J-524217 \| KB-74810 \| MFCD22580423 \| NCGC00346713-05 \| N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-y
CAS number	1035270-39-3	molecular formula	C26H33N5O3
molecular weight	463.57 g/mol	Exact mass	-
PSA	91.500 Å²	logp	3.900

numbering system

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Safety information

pictogram：

GHS06 , GHS08 , GHS07

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H302: 吞食有害 H372: 通过长时间或反复暴露对器官造成损害

Statement of Preventive Measures：

P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。