CAS number：1639351-92-0 molecular formula：C28H39ClN6O6
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC 50 s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay). Form:Solid IC50& Target:Protease Cleavable Cleavable
| Chinese alias | 缬氨酸-西他滨-PAB-Cl | ||
| English alias | N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(chloromethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide | N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(chloromethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl | ||
| CAS number | 1639351-92-0 | molecular formula | C28H39ClN6O6 |
| molecular weight | 591.10 g/mol | Exact mass | - |
| PSA | - | logp | - |
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