Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation. Auristatin F can be used in antibody-drug conjugates (ADC) In Vitro Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has C max of 8276.76 ng/mL. The AUC last is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley ratsDosage: 5 mg/kg Administration: Intravenous injection Result: 1.19 Parameter Dose (i.v.) mg/kg 5 C max (ng/mL) 8276.76 AUC last (min*ng/mL) 62661.30 CL (mL/min/ng) 77.33 Vss (mL/Kg) 1057.13 Form:Solid IC50& Target:Microtubule
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Auristatin F
CAS number：163768-50-1 molecular formula：C40H67N5O8
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| Chinese alias | 奥瑞他汀F | ||
| English alias | - | ||
| CAS number | 163768-50-1 | molecular formula | C40H67N5O8 |
| molecular weight | 746 g/mol | Exact mass | ≥99% |
| PSA | 158.000 Ų | logp | 2.600 |
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