CAY10594是磷脂酶D（PLD）抑制剂。PLD是一种可从磷脂上切割掉头基的酶，产生第二种信使磷脂酸。已鉴定出两种PLD的哺乳动物同工型（PLD1和PLD2），每个都有多个剪接变体。尽管这两种同工型具有相同的功能和结构特征，但它们的调控方式不同，显然具有不同的生物学作用。CAY10594是有效的PC-PLD2抑制剂|（IC | 50 | = 140 nM）。它还在较高浓度（IC | 50 | = 5.1μM）时抑制PC-PLD1。CAY10594在transwell分析中强烈抑制乳腺癌细胞的侵袭性迁移， CAY10594 is a Phospholipase D (PLD) inhibitor. PLD is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD (PLD1 and PLD2) have been identified, with multiple splice variants of each. Although the two isoforms share functional and structural features, they are regulated differently and apparently serve distinct biological roles. CAY10594 is a potent PC-PLD2 inhibitor|in vitro|(IC|50|= 140 nM). It also inhibits PC-PLD1 at higher concentrations (IC|50|= 5.1 μM). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.
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CAY10594
CAS number：1130067-34-3 molecular formula：C26H28N4O2
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| Chinese alias | - | ||
| English alias | BCP30751 | SR-01000928454 | BDBM50278167 | SCHEMBL10311310 | AKOS028114472 | N-[2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl]naphthalene-2-carboxamide | AS-55973 | CHEBI:95023 | EX-A3212 | Q27166784 | HMS3648I04 | N-(2-(4-Oxo-1-phenyl-1,3,8-tr | ||
| CAS number | 1130067-34-3 | molecular formula | C26H28N4O2 |
| molecular weight | 428.53 g/mol | Exact mass | - |
| PSA | 64.700 Ų | logp | 3.900 |
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