compound introduction
MS-PPOH是特异性CYP450同工酶催化的环氧化反应的选择性抑制剂。MS-PPOH抑制CYP4A2和CYP4A3酶通过CYP4A2和CYP4A3酶形成花生四烯酸11,12-环氧化合物，但对CYP4A1的ω-羟基化产物20-HETE的形成没有影响。 MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 μM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.
