乙酰基罗汉松酸酐 （APD）是一种有效的，半合成的肝脏X受体（LXR）激动剂，来自于苹果的提取物。APD与类维生素A X受体（RXR）形成异二聚体，这些化合物一起通过LXR起作用，诱导ABCA1逆向胆固醇转运蛋白的表达并抑制胆固醇的整体吸收（ED | 50 | = 1 nM）。在瞬时反式激活试验中，发现乙酰罗汉果酸酐的效力比22（R）-羟基胆固醇强约1,000倍。APD可用作检测LXR激动剂的阳性对照。 Acetyl podocarpic acid anhydride (APD) is a potent, semi-synthetic liver X receptor (LXR) agonist derived from extracts of the mayapple. APD forms a heterodimer with the retinoid X receptor (RXR), and together these compounds, acting through LXR, induce the expression of the ABCA1 reverse cholesterol transporter and inhibit the overall absorption of cholesterol (ED|50|= 1 nM). In transient transactivation assays, acetyl podocarpic acid anhydride was found to be approximately 1,000 times more potent than 22(R)-hydroxy cholesterol. APD can be used as a positive control for the testing of LXR agonists.
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Acetyl Podocarpic Acid Anhydride
CAS number：344327-48-6 molecular formula：C38H46O7
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Specs
| Chinese alias | - | ||
| English alias | acetyl-podocarpic dimer | ||
| CAS number | 344327-48-6 | molecular formula | C38H46O7 |
| molecular weight | 614.75 g/mol | Exact mass | - |
| PSA | 96.000 Ų | logp | 8.700 |
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