compound introduction
凋亡激活因子VII，热休克蛋白70（Hsp70）是一种细胞可渗透的咪唑化合物，可直接结合抗凋亡伴侣蛋白Hsc70及其诱导型同系物Hsp70（分别为K | d | = 210和140 nM）。已显示热休克蛋白70（Hsp70）能有效抑制SK-OV-3，HCT-15和A549癌细胞系的增殖（分别为IC | 50 | = 220、250和130 nM），并诱导P19胚胎癌中90％的凋亡细胞死亡。和药物治疗12小时（1μM）后的A549肺癌培养物。 Apoptosis Activator VII, Apoptozole is a cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (K|d|= 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC|50|= 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 μM).
