CAS number：957230-65-8 molecular formula：C10H19NO9
异黄酮D-酒石酸盐是人酸β-葡萄糖苷酶的抑制剂。异佛花碱D-酒石酸盐用于治疗高雪氏病。异黄酮D-酒石酸盐已显示在突变的N370S Gaucher成纤维细胞中将溶酶体β-葡萄糖苷酶活性提高了2-3倍。通过与β-葡萄糖苷酶的催化口袋相互作用，异黄酮D-酒石酸盐充当化学伴侣，其通过稳定和/或促进酶的折叠来增加β-葡萄糖苷酶的量。异佛花明D-酒石酸酯也称为酒石酸非替戈酯，（3R，4R，5R）-5-（羟甲基）-3,4-哌啶二醇（2S，3S）-2,3-二羟基丁二酸酯和5R-（羟甲基）-3R ，4R-哌啶二醇，单2S， Afegostat D-Tartrate is a pharmacological chaperone that binds specifically and reversibly with high affinity to acid-β-glucosidase (GCase) in the endoplasmic reticulum.
| Chinese alias | 酒石酸异黄酮 | ||
| English alias | Isofagomine (D-tartrate) | Afegostat D-Tartrate | Afegostat D-Tartrate (D-Isofagomine (D-Tartrate); Isofagomine (D-Tartrate)) | (3R,4R,5R)-5-(HYDROXYMETHYL)-3,4-PIPERIDINEDIOL (2S,3S)-2,3-DIHYDROXYBUTANEDIOATE | A14385 | AKOS030243237 | (2S,3S)-2,3-dihydr | ||
| CAS number | 957230-65-8 | molecular formula | C10H19NO9 |
| molecular weight | 297.26 g/mol | Exact mass | - |
| PSA | 188.000 Ų | logp | - |
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