CAS number：100872-83-1 molecular formula：C14H12N2O4
ML346是 Hsp70 和 HSF-1 活性的激活剂。 ML346 恢复构象疾病模型中的蛋白质折叠，而没有明显的细胞毒性或缺乏特异性。 ML346 诱导了热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加，包括伴侣蛋白如 Hsp70，Hsp40 和 Hsp27。 Information ML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases. Targets HSP70
| Chinese alias | - | ||
| English alias | 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]- | ||
| CAS number | 100872-83-1 | molecular formula | C14H12N2O4 |
| molecular weight | 272.26 g/mol | Exact mass | ≥97% |
| PSA | 84.500 Ų | logp | 1.315 |
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