ELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC 50 value of 34 nM In Vivo ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver . ? ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable . ? ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J mice Dosage: 0.1~1mg/kg Administration: P.o Result: Potently and dose-proportionally suppressed the elongation index in the liver. Animal Model: Male C57BL/6J mice Dosage: 10 mg/kg Administration: P.o Result: Demonstrated highly liver penetrable. Animal Model: Male C57BL/6J mice Dosage: 1 mg/kg Administration: P.o Result: Exhibited sustained plasma exposure. Form:Solid IC50& Target:IC50: 34 nM (ELOVL6)
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ELOVL6-IN-2
CAS number：1067647-43-1 molecular formula：C28H23F6N3O4
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| Chinese alias | - | ||
| English alias | 6,6-dimethyl-3-[5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione | 6,6-dimethyl-3-{5-methyl-3-oxo-2-[4-(trifluoromethoxy)phenyl]-2,3-dihydro-1H-pyrazol-4-yl}-1-phenyl-3-(trifluoromethy | ||
| CAS number | 1067647-43-1 | molecular formula | C28H23F6N3O4 |
| molecular weight | 579.5 g/mol | Exact mass | ≥99% |
| PSA | 79.000 Ų | logp | 5.800 |
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