CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis . In Vitro CORM-401 (100 µM; 1h) induces the NO production in endothelial EA.hy926 cells. CORM-401 (30 µM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels. CORM-401 (50 µM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death. CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells. CORM-401 (10, 30, 100 µM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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CORM-401
CAS number：1001015-18-4 molecular formula：C8H6MnNO6S2
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 1001015-18-4 | molecular formula | C8H6MnNO6S2 |
| molecular weight | 331.2 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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