CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system In Vitro CTX1 binds directly to HdmX to prevent p53-HdmX complex formation, resulting in the rapidly induction of p53 in a DNA damage-independent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo CTX1 ( (30 mg/kg; i.p.; five days a week; for 3 weeks) significantly enhances the survival of mice in AML model system . CTX1 exhibited significant anti-cancer activity alone as well as in combination with nutlin-3 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:p53
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CTX1
CAS number：501935-96-2 molecular formula：C14H10N4
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| Chinese alias | - | ||
| English alias | - | ||
| CAS number | 501935-96-2 | molecular formula | C14H10N4 |
| molecular weight | 234.26 g/mol | Exact mass | ≥97% |
| PSA | 88.700 Ų | logp | 1.500 |
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