BMS-779788 is a LXR partial agonist with IC 50 values of 68 nM for LXR α and 14 nM for LXR β . In Vitro The LXR selective partial agonist BMS-779788 is identified with potent induction of ATP binding transporters ABCA1 and ABCG1 in human whole blood (EC 50 =1.2 μM, 55% efficacy). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BMS-779788 induces LXR target genes in blood in vivo with an EC 50 =610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B . In mice BMS-779788 displays peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 68 nM (LXR α ),14 nM (LXR β )
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BMS-779788
CAS number：918348-67-1 molecular formula：C28H29ClN2O3S
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| Chinese alias | - | ||
| English alias | A903300 | N16812 | EX-A5104 | BDBM50034775 | BMS 788 | XL652 | UNII-FB7ZTJ8M8A | HY-19919 | Floral FC 95 (*potassium salt*) | EXEL 04286652 | AB-131/40227350 | MS-29454 | 1H-Imidazole-4-methanol,2-[1-(2-chlorophenyl)-1-methylethyl]-a,a-dimethyl-1-[3'-(met | ||
| CAS number | 918348-67-1 | molecular formula | C28H29ClN2O3S |
| molecular weight | 509.06 g/mol | Exact mass | ≥99% |
| PSA | 80.600 Ų | logp | 5.700 |
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