CAS number：1358751-06-0 molecular formula：C19H23N3O3S
Osavampator (TAK-653) 是一种新型的 AMPA 受体阳性变构调节剂。Osavampator 以谷氨酸依赖方式选择性结合 AMPA-R，诱导 hGluA1i CHO 细胞 Ca2+ 内流 (EC50 = 3.3 μM)。Osavampator 在许多模型里增强学习和记忆能力。 Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models.
| Chinese alias | 9-(4-(环己基氧基)苯基)-7-甲基-3,4-二氢吡嗪并[2,1-c][1,2,4]噻二嗪 2,2-二氧化物 | ||
| English alias | TAK-653 | CHEMBL4594403 | Pyrazino[2,1-c][1,2,4]thiadiazine, 9-[4-(cyclohexyloxy)phenyl]-3,4-dihydro-7-methyl-, 2,2-dioxide | MS-26031 | 9E3TOE5RIZ | EX-A6607 | SCHEMBL622985 | Osavampator | ||
| CAS number | 1358751-06-0 | molecular formula | C19H23N3O3S |
| molecular weight | 373.47 g/mol | Exact mass | ≥98% |
| PSA | 79.700 Ų | logp | 2.7 |
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