Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor -mediated relea Appearance:Solid IC50& Target:Calcium mobilization TRPM2 channels Endogenous metabolite In Vitro:cADPR (20 nM) elicits a large rapid Ca 2+ release in sea urchin eggs homogenates. cADPR (100 µM; 10 min) induces a sustained elevation of intracellular calcium concentration in a subset (64%) of cultured astrocytes. cADPR (100 µM) and heat (35-3 In Vivo:cADPR (100 µM; push-pull type of brain microperfusion) elevats OT concentrations in ordinate or subordinate mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Biological Activity:Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor -mediated relea
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Cyclic ADP-ribose ammonium
CAS number：unknown molecular formula：C15H21N5O13P2.xNH3
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| Chinese alias | 环状 ADP-核糖铵 | ||
| English alias | - | ||
| CAS number | unknown | molecular formula | C15H21N5O13P2.xNH3 |
| molecular weight | - | Exact mass | ≥99% |
| PSA | - | logp | - |
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