compound introduction
Information Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist ofα4β2 nicotinic acetylcholine receptor (nAChR)andα3β4 nAChRwith EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist ofα7 nAChRswith EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation. Targets α4β2 nAChR (Cell-free assay); α7 nAChRs (Cell-free assay); α3β4 nAChR (Cell-free assay) 2.3 μM(EC50); 18 μM(EC50); 55 μM(EC50)
