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Phenylmagnesium Bromide

Dangerous Goods

CAS number：100-58-3 molecular formula：C6H5BrMg

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

和水剧烈反应。格氏试剂通常以溶液的形式使用，一般呈现为浅灰色至浅棕色透明溶液。它们一般以烷基卤化镁(RMgX)和二烷基镁(R2Mg)的中间态存在，是和复杂组分形成的平衡态混合物 (称为“Schlenk平衡”)。其中的一些种类可能由于溶解度降低而产生沉淀，但这并不会影响它们的实际使用。当出现沉淀时，请轻轻地摇晃瓶子使悬浮物充分分散后使用（如果沉淀物的量非常少，您可以使用悬浮液的上层清液）。特别是在冬天等寒冷的条件下，可能经常生成大量沉淀物。这种情况下，请用干燥的玻璃棒捣碎后使用。另外，您也可以将瓶子放进塑料袋后浸入40℃的水浴中使固体溶解(加热需要专业人员来操作，以防有安全隐患，请注意瓶子开启时有机溶剂的挥发）。

Specs

Chinese alias	溴化苯基镁
English alias	DTXSID3059214 \| Phenylmagnesium bromide 3M in Diethyl Ether \| MFCD00000038 \| phenyl magnesium bromide \| magnesium;benzene;bromide \| SCHEMBL5450 \| CHEBI:51238 \| Phenylmagnesium bromide, 1.0 M in THF \| Bromophenylmagnesium \| Phenylmagnesium bromide 1.0 M in
CAS number	100-58-3	molecular formula	C6H5BrMg
molecular weight	181.31 g/mol	Exact mass	1.0 M in THF
PSA	0.000 Å²	logp	-

numbering system

CAS	100-58-3
ChEBI ID	51238
Wikipedia	Phenylmagnesium_bromide
PubChem CID	66852
Deprecated CAS	26185-68-2
DSSTox Substance ID	DTXSID3059214
European Community (EC) Number	202-867-2
PubChem Reference Collection SID	505857680

physicochemical properties

Density	Relative density: 1.134 mg/L at 25 °C
Color/Form	Liquid
Complexity	100
Exact Mass	179.94250
Formal Charge	0
Chemical Classes	Metals -> Metals, Organic Compounds
Heavy Atom Count	8
Molecular Weight	181.31
Monoisotopic Mass	179.94250
Isotope Atom Count	0
Physical Description	3 molar (76%) solution in diethyl ether: Yellow to brown liquid; [Alfa Aesar MSDS]
Rotatable Bond Count	0
Hydrogen Bond Donor Count	0
Covalently-Bonded Unit Count	3
Hydrogen Bond Acceptor Count	2
Other Experimental Properties	Substances and mixtures, which In contact with water, emit flammable gases
Topological Polar Surface Area	0 Å²
Defined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Undefined Bond Stereocenter Count	0

Safety information

Fire Potential：

Dangerous fire risk, solution highly flammable.

Adverse Effects：

Dermatotoxin - Skin burns.

Hazards Summary：

3 molar solution in diethyl ether (CAS# 60-29-7): Reacts violently with water evolving flammable gases; May form explosive peroxides; Causes burns; [Alfa Aesar MSDS] See Methyl magnesium bromide, Cyclohexylmagnesium chloride, Phenylmagnesium chloride, and Ethyl magnesium bromide.

Disposal Methods：

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Toxicity Summary：

IDENTIFICATION AND USE: Phenylmagnesium bromide is used for chemical Synthesis as Grignard reagent. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: There are no data available.

Regulatory Information：

New Zealand EPA Inventory of Chemical Status: Magnesium, bromophenyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and Categories：

Skin Corr. 1B (100%)

Antidote and Emergency Treatment：

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam...

Protective Action Criteria (PAC)：

PAC-3: 79 [mg/m3]

Military Exposure Guidelines (MEGs)：

collection=toxvaldb&kind=^MEG$

Production methods and uses

Production method

From magnesium and bromobenzene.

purpose

Uses：

Aryl, Chemical Synthesis, Grignard Reagents, Organometallic Reagents

General Manufacturing Information：

Grignard reagents is basically an organomagnesium halide having a formula of RMgX where X is a halogen, and R is an alkyl or aryl (based on a benzene ring) group. On the event of Grignard Reaction, Grignard reagent is added to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. The reaction with formaldehyde leads to a primary alcohol. Grignard reagent can be used for determining the number of halogen atoms present in a halogen compound. ... Used for the chemical analysis of certain triacylglycerols. /Grignard reagents/

upstream information

Methods of Manufacturing：

bromobenzene (CID:7961)

downstream information

No downstream information yet