(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors. In Vitro (RS)-AMPA monohydrate (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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(RS)-AMPA monohydrate
CAS number：76463-67-7 molecular formula：C7H12N2O5
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| Chinese alias | (RS)-AMPA 一水合物 | ||
| English alias | - | ||
| CAS number | 76463-67-7 | molecular formula | C7H12N2O5 |
| molecular weight | 204.18 g/mol | Exact mass | ≥98% |
| PSA | - | logp | - |
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