compound introduction
MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a K i of 0.67 nM for rat mGluR5 In Vitro MFZ 10-7 has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo MFZ 10-7 can lower oral sucrose self-administration rate but has no effect on total sucrose intake . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:rat mGluR5 0.67 nM (Ki)
