AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2 , with an EC 50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1 , 3, 4, 5, 6, 7, and 8 subtypes In Vitro AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC 50 of 195 nM. AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys . AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague-Dawley rats Dosage: 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection; 2 hours before nicotine injections Result: Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats. Form:Solid IC50& Target:mGluR2 285 nM (EC 50 )
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AZD-8529 mesylate
CAS number：1314217-69-0 molecular formula：C25H28F3N5O6S
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| Chinese alias | AZD-8529 甲磺酸盐 | ||
| English alias | AZD-8529 mesylate | 1314217-69-0 | HY-107457A | EX-A7769A | methanesulfonic acid;7-methyl-5-[3-(piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-3H-isoindol-1-one | AC-36778 | 29K1DH0MV7 | HRHCPVNKPOTCGB-UHFFFAOYSA-N | 7- | ||
| CAS number | 1314217-69-0 | molecular formula | C25H28F3N5O6S |
| molecular weight | 583.6 g/mol | Exact mass | ≥99% |
| PSA | 146.000 Ų | logp | - |
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