compound introduction
美芬丁胺是苯胺类药物的成员。
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
N,2-dimethyl-1-phenylpropan-2-amine
CAS number：100-92-5 molecular formula：C11H17N
overview
Specs
| Chinese alias | - | ||
| English alias | N,2-Dimethyl-1-phenyl-propan-2-amine | ||
| CAS number | 100-92-5 | molecular formula | C11H17N |
| molecular weight | 163.26 | Exact mass | - |
| PSA | 12 | logp | 2.4 |
numbering system
| CAS | 100-92-5 |
| UNII | TEZ91L71V4 |
| HMDB ID | HMDB0015452 |
| KEGG ID | D08180 |
| ChEBI ID | 6755 |
| Wikidata | Q6817800 |
| ChEMBL ID | CHEMBL1201234 |
| Wikipedia | Mephentermine |
| DrugBank ID | DB01365 |
| DrugCentral | 1694 |
| PharmGKB ID | PA164745533 |
| PubChem CID | 3677 |
| Related CAS | 1212-72-2 (sulfate (2:1)) |
| Nikkaji Number | J4.989A |
| Pharos Ligand ID | V91V6BZKU5LZ |
| NCI Thesaurus Code | C66089 |
| DSSTox Substance ID | DTXSID4023256 |
| Metabolomics Workbench ID | 43521 |
| European Community (EC) Number | 202-901-6 |
| PubChem Reference Collection SID | 505806721 |
| International Nonproprietary Names (INN) | MEPHENTERMINE |
physicochemical properties
| pH | ALKALINE REACTION |
| Odor | FISHY AMINE ODOR |
| XLogP3 | 2.4 |
| Color/Form | LIQUID |
| Complexity | 123 |
| Exact Mass | 163.136099547 |
| Solubility | 4.57e-01 g/L |
| Human Drugs | Pharmaceuticals |
| Formal Charge | 0 |
| Melting Point | < 25 °C |
| Heavy Atom Count | 12 |
| Molecular Weight | 163.26 |
| Monoisotopic Mass | 163.136099547 |
| Isotope Atom Count | 0 |
| Physical Description | Solid |
| Rotatable Bond Count | 3 |
| Dissociation Constants | iupacpka |
| Kovats Retention Index | Standard polar: 1685 |
| Collision Cross Section | 135.95 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards] |
| Hydrogen Bond Donor Count | 1 |
| Covalently-Bonded Unit Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Other Experimental Properties | WHITE CRYSTALS OR CRYSTALLINE POWDER; ODORLESS; SOLUTIONS ARE ACID TO LITMUS, HAVING A PH OF ABOUT 6 /SULFATE/ |
| Topological Polar Surface Area | 12 Ų |
| Defined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
Safety information
Disposal Methods：
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Storage Conditions：
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), unless otherwise specified by manufacturer. Protect from freezing.
Human Toxicity Excerpts：
Dependence on mephentermine, a widely used sympathomimetic pressor agent, is so far unreported, although misuse of inhalers is recognized. A case of mephentermine dependence associated with chronic psychosis is reported here. Psychosis initially surfaced with chronic dexamphetamine abuse, but was sustained for 3 yr by mephentermine. After a period of remission lasting for 4 years, the patient again developed psychosis on restarting abuse of mephentermine, which lasted for S years.
Hazard Classes and Categories：
STOT SE 3 (100%)
Antidote and Emergency Treatment：
Recommended treatment for overdose includes: For excessive hypertensive effect: The rate of administration should be reduced or the mediation temporarily discontinued until blood pressure is decreased. Additional measures are usually not necessary because the duration of action of these agents is short. However, if reduction in the rate of administration or discontinuation of therapy fails to lower the blood pressure, a short-acting alpha-adrenergic blocking agent may be administered. /Sympathomimetic agents - cardiovascular use/
Production methods and uses
Production method
PREPARED BY HYDROGENATING 1-CHLORO-2-METHYLAMINO -2-METHYL-1-PHENYLPROPANE HYDROCHLORIDE IN METHANOL IN THE PRESENCE OF PALLADIUM BARIUM CARBONATE.
purpose
Uses：
MEDICATION
Use Classification：
Pharmaceuticals
General Manufacturing Information：
THE FREE BASE IS SUFFICIENTLY VOLATILE THAT IT CAN BE USED IN INHALERS, WHICH IS THE ONLY TYPE OF PRODUCT OF THE FREE BASE THAT IS MARKETED.
Related
upstream information
Methods of Manufacturing：
METHANOL (CID:887); Mephentermine (CID:3677)
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
