CAS number：1026785-59-0 molecular formula：C25H35NO4S
Lomibuvir (VX-222, VCH-222)是一种新型的，有效的，选择性的HCV聚合酶抑制剂，IC50为0.94-1.2 μM，作用于突变型M423T效果低15.3倍，作用于突变型I482L效果低108倍。Phase 2。 Applications： In HCV replicon cells, VX-222 dose-dependently increases IFN-β promoter activity by 5.0-fold and inhibits HCV activity with EC50 and EC90 values of 0.3 and 12 nM, respectively. Also, VX-222 rescues the Sendai virus-activated Rig-I pathway due to the inhibition of viral replication.
| Chinese alias | - | ||
| English alias | AS-19557 | 1026785-55-6 (or 1026785-59-0) | NCGC00386146-02 | SCHEMBL15498313 | VCH222 | VCH-222 | s1480 | VX-222 (VCH-222, Lomibuvir) | EINECS 202-403-9 | KBio3_002752 | LOMIBUVIR [INN] | 5-(3,3-dimethyl-but-1-ynyl)-3-[(cis-4-hydroxy-cyclohexyl)-(trans-4 | ||
| CAS number | 1026785-59-0 | molecular formula | C25H35NO4S |
| molecular weight | 445.63 g/mol | Exact mass | ≥99% |
| PSA | 106.000 Ų | logp | 5.900 |
No numbering system information yet
No physical and chemical property information yet
No safety information yet
No production method and use information yet
No upstream information yet
No downstream information yet
