Actinonin ((-)-Actinonin) 是一种由放线菌产生的天然抗菌剂。Actinonin 抑制氨肽酶 M，氨肽酶 N 和亮氨酸氨肽酶。Actinonin 是一种有效的可逆肽去甲酰基酶 (PDF) 抑制剂，Ki 为 0.28 nM。Actinonin 还抑制 MMP-1，MMP-3，MMP-8，MMP-9 和 hmeprin α 的 Ki 值分别为 300 nM，1,700 nM，190 nM，330 nM 和 20 nM。Actinonin 是一种凋亡诱导剂，具有抗增殖和抗肿瘤活性。 Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
Actinonin
CAS number：13434-13-4 molecular formula：C19H35N3O5
overview
compound introduction
Specs
| Chinese alias | (3R)-3-[[((1S)-1-[[(2S)-2-(羟甲基)-1-吡咯烷基]羰基]-2-甲基丙基]氨基甲酰基]辛基异羟肟酸 | ||
| English alias | DivK1c_001024 | NCGC00093535-03 | SR-01000075681 | Tox21_500010 | AKOS015894413 | SR-01000075681-1 | DB04310 | BRD-K24621118-001-02-5 | BRD-K24621118-001-03-3 | NCGC00093535-02 | UNII-P18SPA8N0K | 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEPTANOIC ACID [1-(2-HYD | ||
| CAS number | 13434-13-4 | molecular formula | C19H35N3O5 |
| molecular weight | 385.50 g/mol | Exact mass | ≥98% |
| PSA | 119.000 Ų | logp | 1.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
No safety information yet
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
