Leucinostatin A是由Paaccilomyces lilacinus |生产的非典型非肽复合物的主要成分，该复合物于1973年首次报道。Leucinostatin对革兰氏阳性细菌，真菌，植物和肿瘤细胞系具有广泛的生物活性。白细胞抑素A通过解偶联氧化磷酸化抑制呼吸作用，并被文丘里汀和寡霉素等抑制剂增强。最近，对亮氨酸抑制素的兴趣集中在理解其作为胰岛素样生长因子I调节剂，离子载体，病毒糖蛋白的细胞表面表达抑制剂及其抗锥虫活性的活性。 Leucinostatin A is the major component of an atypical nonapeptide complex produced by|Paecilomyces lilacinus|, first reported in 1973. Leucinostatins display broad bioactivity against Gram positive bacteria, fungi, plants and tumour cell lines. Leucinostatin A inhibits respiration by uncoupling oxidative phosphorylation and is potentiated by inhibitors such as venturicidin and oligomycin. More recently, interest in leucinostatin has focused on understanding its activity as an insulin-like growth factor I regulator, an ionophore, inhibitor of cell surface expression of viral glycoproteins and its anti- trypanosomal activity.
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Leucinostatin A
CAS number：76600-38-9 molecular formula：C62H111N11O13
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| Chinese alias | - | ||
| English alias | Antibiotic CC 1014 | Antibiotic 1907-VIII | Paecilotoxin A | P-168 | .beta.-Alaninamide,6S)-6-hydroxy-4-methyl-8-oxo- L-2-aminodecanoyl-threo-3-hydroxy-L-leucyl- 2-methylalanyl-L-leucyl-L-leucyl-2-methylalanyl- 2-methylalanyl-N-[2-(dimethylamino)-1-methyl | ||
| CAS number | 76600-38-9 | molecular formula | C62H111N11O13 |
| molecular weight | 1218.61 g/mol | Exact mass | ≥95% |
| PSA | - | logp | - |
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