compound introduction
16,16-二甲基前列腺素A1是PGA1的抗代谢类似物，在体外不会抑制细胞DNA合成的浓度抑制HSV和HIV-1感染系统中的病毒复制。Vero细胞和人包皮成纤维细胞中HSV-1菌株的ID | 50 |值分别为3.8-5.6 µg / ml和4.6-7.3 µg / ml。急性感染HIV-1的T细胞的ID | 50 |为2.5 µg / ml。 16,16-dimethyl Prostaglandin A1 is a metabolism resistant analog of PGA1 that inhibits the viral replication in both HSV and HIV-1 infection systems|in vitro|at concentrations that do not adversely alter cellular DNA synthesis. The ID|50|values for HSV-1 strains in vero cells and human foreskin fibroblasts are 3.8-5.6 μg/ml and 4.6-7.3 μg/ml, respectively. The ID|50|for T cells acutely infected with HIV-1 is 2.5 μg/ml.
