LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC 50 s of In Vitro LHF-535 is a small-molecule viral entry inhibitor that targets the arenavirus envelope glycoprotein (GP). LHF-535 exhibits potent antiviral activity against a broad array of hemorrhagic fever arenaviruses. LHF-535 inhibits Lassa GP-pseudotyped lentivirus with an IC 50 of 0.1-0.3 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver. An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection, demonstrating that LHF-535 is efficacious as a post-exposure therapeutic in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: IFN-α/β and-γ receptor-deficient AG129 miceDosage: 3, 10, or 30 mg/kg/day Administration: Orally; daily; 14 days Result: Effective as a post-exposure therapeutic. Form:Solid
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LHF-535
CAS number：1450929-77-7 molecular formula：C27H28N2O2
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| Chinese alias | - | ||
| English alias | LHF-535 | Benzenemethanol, alpha,alpha-dimethyl-4-((1Z)-2-(1-(4-(1-methylethoxy)phenyl)-1H-benzimidazol-5-yl)ethenyl)- | UNII-BET7FM8SQG | (Z)-2-(4-(2-(1-(4-Isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol | 2-[4-[(Z)-2-[1-(4-propan-2-y | ||
| CAS number | 1450929-77-7 | molecular formula | C27H28N2O2 |
| molecular weight | 412.52 g/mol | Exact mass | ≥99% |
| PSA | 47.300 Ų | logp | 5.800 |
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