NIAD-4

可透过血脑屏障 (BBB) 的远红光（近红外）荧光造影剂，用于对淀粉样斑块进行高特异性的原位和体内染色。 NIAD-4 是一种可透过血脑屏障 (BBB) 的远红光（近红外）荧光造影剂，用于对淀粉样斑块进行高特异性的原位染色（DMSO/丙二醇溶液中 10 μM；APP 小鼠冠状切片）和体内染色（APP 小鼠静脉注射 2 mg/kg）。由于其推拉结构设计以及显著增强的硫代黄素T (ThT) 位点亲和力（Ki = 10 nM/NIAD-4 vs 580 nM/ThT），NIAD-4 在与聚集的淀粉样β蛋白 1-40 (PBS 中 4.1 μM NIAD-4 和 10 μM 淀粉样β蛋白) 结合后，吸收光明显红移 (~70 nm)，消光系数增加 1.3 倍。激发光 450-488 nm，发射光 550-650 nm。 A far-red (near-infrared) fluorescent contrast agent that permeates the blood-brain barrier (BBB) ​​for highly specific in situ and in vivo staining of amyloid plaques. NIAD-4 is a far-red (near-infrared) fluorescent contrast agent that permeates the blood-brain barrier (BBB) ​​for highly specific in situ staining of amyloid plaques (10 μM in DMSO/propylene glycol solution; coronal sections of APP mice) and in vivo staining (2 mg/kg intravenous injection in APP mice). Due to its push-pull design and significantly enhanced affinity for the thioflavin T (ThT) site (Ki = 10 nM/NIAD-4 vs 580 nM/ThT), NIAD-4 exhibits a significant red-shift in absorbance (~70 nm) and a 1.3-fold increase in extinction coefficient upon binding to aggregated amyloid-β 1-40 (4.1 μM NIAD-4 and 10 μM amyloid-β in PBS). Excitation light 450-488 nm, emission light 550-650 nm.

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