CAS number：862269-92-9 molecular formula：C25H25FN6O2S
(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628. (S)-AMG-628 is the orally active antagonist for TRPV1 , that inhibits the Capsaicin - and acid-induced Ca 2+ -influx with IC 50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin -induced rats flinching, and reverses the thermal hypersensitivity in CFA- induced inflammatory pain models.
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| CAS number | 862269-92-9 | molecular formula | C25H25FN6O2S |
| molecular weight | 492.57 g/mol | Exact mass | - |
| PSA | - | logp | - |
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