Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.An antiangiogenic and antiinflammatory agonist of TRPV1. Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. An antiangiogenic and antiinflammatory agonist of TRPV1.
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(±)-Evodiamine
CAS number：518-18-3 molecular formula：C19H17N3O
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| Chinese alias | 吴茱萸胺 | ||
| English alias | XE178590 | AS-15078 | HY-N0114A | NCGC00163553-02 | SureCN682158 | FT-0651829 | Evodiamine, Evodia rutaecarpa | NSC258314 | NSC-258314 | Evodiamine; | NCGC00163553-03 | Q5418554 | PubChem18244 | (1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.0^{2,10.0^{4, | ||
| CAS number | 518-18-3 | molecular formula | C19H17N3O |
| molecular weight | 303.37 g/mol | Exact mass | ≥98% |
| PSA | 39.300 Ų | logp | 3.100 |
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