compound introduction
GDC-0068(RG 7440)是泛Akt抑制剂，对Akt1/2/3的IC50分别为5 nM/18 nM/8 nM，比对PKA的抑制性高620倍。 GDC-0068(RG 7440) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA.
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GDC-0068
CAS number：1001264-89-6 molecular formula：C24H32ClN5O2
overview
Specs
| Chinese alias | 帕他色替 | ||
| English alias | RG7440 | GDC0068 | GDC 0068 | RG-7440 | RG 7440 | DTXSID9041152 | Ipatasertib; GDC-0068 | NCGC00182063-03 | AS-17027 | 0RF | IPATASERTIB [WHO-DD] | (2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperaz | ||
| CAS number | 1001264-89-6 | molecular formula | C24H32ClN5O2 |
| molecular weight | 458 g/mol | Exact mass | - |
| PSA | 81.600 Ų | logp | 2.5 |
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