CAS number：1000669-72-6 molecular formula：C20H20N4O
KW-2449能较强地抑制Flt3，IC50为6.6 nM，对FGFR1，Bcr-Abl和Aurora A的抑制性适中，而对 PDGFRβ，IGF-1R，EGFR则无抑制性。A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase。 KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 with IC50 of 6.6 nM, modestly potent to FGFR1, Bcr-Abl and Aurora A; little effect on PDGFRβ, IGF-1R, EGFR. A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase。
| Chinese alias | - | ||
| English alias | (E)-1-{4-[2-(1H-indazol-3-yl)vinyl]benzoyl}piperazine | NCGC00346569-07 | (E)-(4-(2-(1H-Indazol-3-yl)vinyl)-phenyl)(piperazin-1-yl)methanone | (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone | AC-28419 | NSC800778 | NSC-800778 | KW-2449 | ||
| CAS number | 1000669-72-6 | molecular formula | C20H20N4O |
| molecular weight | 332.4 g/mol | Exact mass | - |
| PSA | 61.000 Ų | logp | 2.700 |
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